ZEISS Lattice Lightsheet 7

Long-term volumetric imaging of living cells

Lattice light sheet technology hit the headlines following the landmark paper in 2014 and has proved to be an extremely powerful approach for the long-term study of live specimens, generating numerous high impact publications. However, the scope and usability of this approach has been limited to a small number of users. The ZEISS Lattice Lightsheet 7 provides a convenient, inverted configuration that is compatible with the same samples and sample preparation you would use when imaging with a confocal or spinning disc, for example.

The automatic alignments and easy workflows of the Lattice Lightsheet 7 mean that even inexperienced users can now access this cutting-edge approach and capture 3D data over hours and days at a time. The accessibility of such powerful technology to a wide user base sets this approach to become the new standard in 3D long term timelapse imaging of dish mounted specimens and there are already numerous installations providing routes to address new questions that have previously been unattainable.

Since its initial development by Eric Betzig and his team in 2011, the technology has been on an extensive 10 year journey of evolution. Follow the story below to see how what started as a complex, home-built system that could almost fill a room, has now become a compact, inverted and user-friendly feat of engineering that can fit on a desk…

Evolution of Lattice Lightsheet Technology:

Key Milestones

December 2011

First exposure using the ground-breaking homebuilt Lattice Lightsheet system, developed by Eric Betzig and his team at Janelia Research Campus.

November 2013

A concept is developed for an inverted system configuration and compatibility with standard samples.

September 2014

ZEISS and the Howard Hughes Medical Institute’s Janelia Research Campus sign an exclusive license agreement for the commercialisation of Lattice light sheet microscopy and development of a turnkey ZEISS system.

October 2014

Eric Betzig is jointly awarded The Nobel Prize in Chemistry for “the development of super-resolved fluorescence microscopy” and landmark paper “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution” is published in Science Magazine.

September 2016

First biological data is acquired from demonstrator setup, at Carl Zeiss Microscopy, Jena.

November 2017

Product engineering begins.
1. Implementation of a range of optical improvements through the development of autoimmersion, transmission and aberration correction features.
2. Development of software for improved system control, processing, data handling and auto alignment.

November 2019

Beta testing programme begins at nine sites worldwide, with pre-serial systems placed in the United States, Australia, Germany, Switzerland, Sweden and the Netherlands.

December 2020

Official launch of the series system ZEISS Lattice Lightsheet 7, making Lattice Light Sheet technology accessible to everyone - with its automatic alignments, easy workflows, inverted design and compatibility with standard sample carriers.

July 2021

University of Oxford trailblaze with the first official installation of the ZEISS Lattice Lightsheet 7 globally, in a project led by Marco Fritzsche, Associate Professor and Rosalind Franklin Kennedy Trust Research Fellow at The Kennedy Institute of Rheumatology.


Introducing the turnkey solution:

ZEISS Lattice Lightsheet 7

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