Evolution of Lattice Lightsheet Technology:
The journey to ZEISS Lattice Lightsheet 7

ZEISS Lattice Lightsheet 7
Long-term volumetric imaging of living cells
Lattice light sheet technology hit the headlines following the landmark paper in 2014 and has proved to be an extremely powerful approach for the long-term study of live specimens, generating numerous high impact publications. However, the scope and usability of this approach has been limited to a small number of users. The ZEISS Lattice Lightsheet 7 provides a convenient, inverted configuration that is compatible with the same samples and sample preparation you would use when imaging with a confocal or spinning disc, for example.

The automatic alignments and easy workflows of the Lattice Lightsheet 7 mean that even inexperienced users can now access this cutting-edge approach and capture 3D data over hours and days at a time. The accessibility of such powerful technology to a wide user base sets this approach to become the new standard in 3D long term timelapse imaging of dish mounted specimens and there are already numerous installations providing routes to address new questions that have previously been unattainable.
Since its initial development by Eric Betzig and his team in 2011, the technology has been on an extensive 10 year journey of evolution. Follow the story below to see how what started as a complex, home-built system that could almost fill a room, has now become a compact, inverted and user-friendly feat of engineering that can fit on a desk…