Evolution of Lattice Lightsheet Technology:

First exposure using the ground-breaking homebuilt Lattice Lightsheet system, developed by Eric Betzig and his team at Janelia Research Campus.

A concept is developed for an inverted system configuration and compatibility with standard samples.

ZEISS and the Howard Hughes Medical Institute’s Janelia Research Campus sign an exclusive license agreement for the commercialisation of Lattice light sheet microscopy and development of a turnkey ZEISS system.

Eric Betzig is jointly awarded The Nobel Prize in Chemistry for “the development of super-resolved fluorescence microscopy” and landmark paper “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution” is published in Science Magazine.

First biological data is acquired from demonstrator setup, at Carl Zeiss Microscopy, Jena.

Product engineering begins.
1. Implementation of a range of optical improvements through the development of autoimmersion, transmission and aberration correction features.
2. Development of software for improved system control, processing, data handling and auto alignment.

Beta testing programme begins at nine sites worldwide, with pre-serial systems placed in the United States, Australia, Germany, Switzerland, Sweden and the Netherlands.

Official launch of the series system ZEISS Lattice Lightsheet 7, making Lattice Light Sheet technology accessible to everyone - with its automatic alignments, easy workflows, inverted design and compatibility with standard sample carriers.

University of Oxford trailblaze with the first official installation of the ZEISS Lattice Lightsheet 7 globally, in a project led by Marco Fritzsche, Associate Professor and Rosalind Franklin Kennedy Trust Research Fellow at The Kennedy Institute of Rheumatology.